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Povarov reaction
The Povarov reaction is an organic reaction described as a formal cycloaddition between an aromatic imine and an alkene. The imine in this organic reaction is a condensation reaction product from an aniline type compound and a benzaldehyde type compound.〔Povarov, L. S.; Mikhailov, B. M. Izv. Akad. Nauk SSR, Ser. Khim. 1963, 953–956.〕〔Povarov, L. S.; Grigos, V. I.; Mikhailov, B. M. Izv. Akad. Nauk SSR, Ser. Khim. 1963, 2039–2041.〕〔Povarov, L. S. ''Russian Chem. Rev.'' 1967, 36, 656.〕 The alkene must be electron rich which means that functional groups attached to the alkene must be able to donate electrons. Such alkenes are enol ethers and enamines. The reaction product in the original Povarov reaction is a quinoline. Because the reactions can be carried out with the three components premixed in one reactor it is an example of a multi-component reaction.
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==Reaction mechanism==
The reaction mechanism for the Povarov reaction to the quinoline is outlined in ''scheme 1''. In step one aniline and benzaldehyde react to the Schiff base in a condensation reaction. The Povarov reaction requires a lewis acid such as boron trifluoride to activate the imine for an electrophilic addition of the activated alkene. This reaction step forms an oxonium ion which then reacts with the aromatic ring in a classical electrophilic aromatic substitution. Two additional elimination reactions create the quinoline ring structure.
The reaction is also classified as a subset of aza Diels-Alder reactions 〔''Recent synthetic developments in a powerful imino Diels–Alder reaction (Povarov reaction): application to the synthesis of N-polyheterocycles and related alkaloids'' Vladimir V. Kouznetsov Tetrahedron 65 (2009) 2721–2750 〕
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